The dermatologist scrapes or shaves off the BCC using a curette (a sharp instrument with a ring-shaped tip), then uses heat or a chemical agent to destroy remaining cancer cells, stop the bleeding and seal off the wound. click here to buy imiquimod 5% cream online The physician may repeat the procedure a few times during the same session until no cancer cells remain. Typically, the procedure leaves a round, whitish scar resembling a cigarette burn at the surgery site.
Exposure to sunlight (including sunlamps) should be avoided or minimized during use of Aldara Cream because of concern for heightened sunburn susceptibility. Patients should be warned to use protective clothing (e.g., a hat) when using Aldara Cream. Patients with sunburn should be advised not to use Aldara Cream until fully recovered. Patients who may have considerable sun exposure, e.g., due to their occupation, and those patients with inherent sensitivity to sunlight should exercise caution when using Aldara Cream.
Aldara Cream shortened the time to skin tumor formation in an animal photoco-carcinogenicity study . The enhancement of ultraviolet carcinogenicity is not necessarily dependent on phototoxic mechanisms. Therefore, patients should minimize or avoid natural or artificial sunlight exposure.
In 2 key, randomised controlled trials the pooled clearance rate with imiquimod therapy was 82% (95% CI 76% to 87%), assessed by completely excising the treatment site at 12 weeks post treatment and evaluating it histologically. 11 Other trials have shown similar short-term clearance rates. 6,12 In an ongoing open-label trial the estimated clinical clearance rate with imiquimod, based on 3 years’ follow-up, was 81% (95% CI 75% to 86%). 7,13 The rate of recurrence beyond 3 years is unknown. While there are no trials directly comparing imiquimod with surgical excision, imiquimod appears less effective than excision.